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　　細(xì)胞名稱：人霍奇金淋巴瘤細(xì)胞KM-H2

產(chǎn)品規(guī)格：T25培養(yǎng)瓶x1；1.5ml凍存管x2

細(xì)胞數(shù)量：1x10^6；1x10^6

保存溫度：37℃；-198℃

運(yùn)輸方式：常溫保溫運(yùn)輸；干冰運(yùn)輸

安全等級：1

用途限制：僅供科研3類

培養(yǎng)體系：DMEM(HYCLONE SH30022.01)+10%FBS+1%三抗

培養(yǎng)溫度：37℃

二氧化碳濃度：5%

簡介：人霍奇金淋巴瘤細(xì)胞KM-H2取自37歲男性供體，懸浮培養(yǎng)。

注釋

Part of:Cancer Cell Line Encyclopedia(CCLE)project.

Part of:COSMIC cell lines project.

Part of:LL-100 blood cancer cell line panel.

Part of:MD Anderson Cell Lines Project.

Doubling time:~48 hours(DSMZ).

Microsatellite instability:Stable(MSS)(Sanger).

Omics:Cell surface proteome.

Omics:Deep exome analysis.

Omics:Deep RNAseq analysis.

Omics:DNA methylation analysis.

Omics:Protein expression by reverse-phase protein arrays.

Omics:SNP array analysis.

Omics:Transcriptome analysis.

Omics:Virome analysis using RNAseq.

Misspelling:KHM2/171877;In IPD-IMGT/HLA 15116.

Derived from sampling site:Pleural effusion.

基因突變

CIITA-C15orf65 gene fusion(PubMed=21368758).

PRRC2B-MGMT(BAT2L1-MGMT)gene fusion(PubMed=21368758)

HLA信息

Class I

HLA-A A*24:02

HLA-B B*15:01,52:01

HLA-C C*04:01,12:02

Class II

HLA-DP DPB1*02:01,05:01

HLA-DQ DQA1*03:01,05:05

DQB1*03:01,03:02

HLA-DR DRB1*04:65,11:01

DRB3*02:02

DRB4*01:03

STR信息

Amelogenin X

CSF1PO 10,14

D5S818 11,13

D7S820 10,11,12

D13S317 10,11

D16S539 9

TH01 7,9

TPOX 8,11,12(Cosmic-CLP)

8,10,11(DSMZ)

vWA 17,18

參考文獻(xiàn)

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Cytochemical,immunologic,chromosomal,and molecular genetic analysis of a novel cell line derived from Hodgkin's disease.

Blood 68:285-292(1986)

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Reed-Sternberg cells in Hodgkin's cell lines HDLM,L-428,and KM-H2 are not actively replicating:lack of bromodeoxyuridine uptake by multinuclear cells in culture.

Blood 71:1382-1389(1988)

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A new hypothesis on the cellular origin of Reed-Sternberg and Hodgkin cells based on the immunological and molecular genetic analysis of the KM-H2 line.

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Biology of Hodgkin cell lines.

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Siebert R.,Willers C.P.,Schramm A.,Fossa A.,Dresen I.M.G.,Uppenkamp M.,Nowrousian M.R.,Seeber S.,Opalka B.

Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.

Br.J.Haematol.91:350-354(1995)

PubMed=8558920

Dirks W.G.,Zaborski M.,Jager K.,Challier C.,Shiota M.,Quentmeier H.,Drexler H.G.

The(2;5)(p23;q35)translocation in cell lines derived from malignant lymphomas:absence of t(2;5)in Hodgkin-analogous cell lines.

Leukemia 10:142-149(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5

Drexler H.G.

The leukemia-lymphoma cell line factsbook.

(In)ISBN 9780122219702;pp.1-733;Academic Press;London(2001)

PubMed=17065008;DOI=10.1080/10428190600667721

Feuerborn A.,Moritz C.,Von Bonin F.,Dobbelstein M.,Trumper L.,Sturzenhofecker B.,Kube D.

Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.

Leuk.Lymphoma 47:1932-1940(2006)

PubMed=18194364;DOI=10.1111/j.1399-0039.2007.01001.x

Witter K.,Mautner J.,Volgger A.,Zahn R.,Kauke T.

A novel HLA-DRB1 allele,HLA-DRB1*0465,was identified in a Hodgkin's lymphoma cell line.

Tissue Antigens 71:257-258(2008)

PubMed=20164919;DOI=10.1038/nature08768

Bignell G.R.,Greenman C.D.,Davies H.,Butler A.P.,Edkins S.,Andrews J.M.,Buck G.,Chen L.,Beare D.,Latimer C.,Widaa S.,Hinton J.,Fahey C.,Fu B.,Swamy S.,Dalgliesh G.L.,Teh B.T.,Deloukas P.,Yang F.,Campbell P.J.,Futreal P.A.,Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

PubMed=21368758;DOI=10.1038/nature09754

Steidl C.,Shah S.P.,Woolcock B.W.,Rui L.,Kawahara M.,Farinha P.,Johnson N.A.,Zhao Y.,Telenius A.,Neriah S.B.,McPherson A.,Meissner B.,Okoye U.C.,Diepstra A.,van den Berg A.,Sun M.,Leung G.,Jones S.J.,Connors J.M.,Huntsman D.G.,Savage K.J.,Rimsza L.M.,Horsman D.E.,Staudt L.M.,Steidl U.,Marra M.A.,Gascoyne R.D.

MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers.

Nature 471:377-381(2011)

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細(xì)胞操作說明書下載：細(xì)胞操作說明